The Big Bang Theory has proved to be one of the most successful sitcoms in television history, portraying quirky and sometimes sharply idiosyncratic scientists in an affectionate and fun-loving light. The humor has helped bring topics like particle physics and neuroscience into many people’s living rooms. But to play these scientists, actors have had to cast aside their normal appearances to get weird. Here, we’ll look at what some of the most famous TV show–scientists look like both on and off the screen. The comparisons might amaze you.